Chemistry
Heterocyclic Building Blocks
Pyrimidines
5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
Substitution Reactions: Depending on the substituents on the ring, you can perform various substitution reactions. For example, you can perform nucleophilic aromatic substitution (SNAr) if there are suitable leaving groups or electrophilic aromatic substitution if there are electron-rich groups.
Oxidation/Reduction Reactions: You can perform oxidation or reduction reactions on the heterocyclic ring, typically using appropriate reagents and conditions.
Ring Opening: Under certain conditions, the ring can undergo ring-opening reactions, forming open-chain compounds. The exact conditions and mechanisms will depend on the specific structure.
Cyclization Reactions: If you have suitable functional groups, you can cyclize the compound to form other fused or spirocyclic heterocycles.
Alkylation and Acylation: You can alkylate or acylate the nitrogen atoms in the ring using appropriate alkylating or acylating agents.
Cross-Coupling Reactions: If you have aryl or vinyl groups, you can perform cross-coupling reactions such as Suzuki-Miyaura, Heck, or Sonogashira reactions.
Hydrogenation: You can hydrogenate the double bonds in the ring to reduce them to single bonds, typically using a hydrogenation catalyst.
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tert-Butyl 4-chloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
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tert-Butyl 2-chloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
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5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine hydrochloride
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tert-Butyl 7,8-dihydro-2-(methylsulfonyl)pyrido[4,3-d]pyrimidine-6(5H)-carboxylate
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tert-Butyl 2-amino-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
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tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
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tert-Butyl 4-chloro-2-methyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
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6-Methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine
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5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine
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N,N-Dimethyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine dihydrochloride
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2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride
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tert-Butyl 7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate
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4-Chloro-6-isopropyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
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2-Chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride
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5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidin-2-amine dihydrochloride
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5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidine dihydrochloride
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5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidin-2-ol hydrochloride