Chemistry Heterocyclic Building Blocks Pyridines 5,6-dichloropyridin-2-amine
Ambeed provide 4 derivatives of 5,6-dichloropyridin-2-amine.
These compounds have the same murcko framework: 5,6-dichloropyridin-2-amineNucleophilic substitution: The amino group can undergo nucleophilic substitution reactions with electrophiles. For example, it can react with alkyl halides to form N-alkylated products.
Acylation: The amino group can react with acyl chlorides or acid anhydrides to form amides.
Reductive amination: The amino group can undergo reductive amination with carbonyl compounds in the presence of reducing agents to form secondary amines.
Suzuki coupling: The pyridine ring, especially with the chlorine atoms as directing groups, can undergo Suzuki coupling reactions with aryl boronic acids to introduce aryl substituents at the 2-position.
Halogenation reactions: The chlorine atoms can be substituted with other halogens (e.g., bromination or iodination) under appropriate conditions.
Amide formation: The amino group can react with carboxylic acids to form amides.
Metal complexation: The pyridine nitrogen can coordinate with transition metals to form metal complexes.
Condensation reactions: The compound can undergo condensation reactions with appropriate reagents to form heterocyclic compounds.
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