Chemistry Heterocyclic Building Blocks Pyridines 5-(trifluoromethyl)pyridin-2-ol
Ambeed provide 8 derivatives of 5-(trifluoromethyl)pyridin-2-ol.
These compounds have the same murcko framework: 5-(trifluoromethyl)pyridin-2-olAcid-Base Reactions: The hydroxyl group can act as a weak acid and undergo protonation or deprotonation reactions in the presence of strong acids or bases, respectively.
Nucleophilic Substitution: The hydroxyl group can undergo substitution reactions with suitable nucleophiles. Similarly, the pyridine ring can undergo substitution reactions at the 2-position.
Oxidation: The hydroxyl group can be oxidized to form a ketone or carboxylic acid depending on the oxidizing agent and reaction conditions.
Esterification: The hydroxyl group can undergo esterification reactions with carboxylic acids or acid chlorides to form esters.
Reduction: The carbonyl group can be reduced to form a primary alcohol or further reduced to a hydrocarbon using reducing agents.
Halogenation: The pyridine ring can undergo halogenation reactions with halogenating agents to introduce halogen atoms onto the ring.
Metalation: The pyridine ring can be metalated using strong bases, forming metal complexes.
Condensation Reactions: The compound can participate in condensation reactions, such as the synthesis of heterocyclic compounds or Mannich-type reactions.
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4-Bromo-5-(trifluoromethyl)pyridin-2-ol
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4-Iodo-5-(trifluoromethyl)pyridin-2-ol
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3-Nitro-5-(trifluoromethyl)pyridin-2-ol
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3-Fluoro-5-(trifluoromethyl)pyridin-2-ol
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2-Hydroxy-5-(trifluoromethyl)nicotinaldehyde