Chemistry
Heterocyclic Building Blocks
Pyridines
5-bromo-2-chloro-4-methylpyridine
Substitution Reactions: The bromine and chlorine atoms can be substituted with other functional groups or atoms through nucleophilic substitution reactions.
Nucleophilic Aromatic Substitution (SNAr): The bromine and chlorine atoms make the compound susceptible to nucleophilic aromatic substitution reactions where a nucleophile can replace either of these halogens.
Metalation Reactions: The pyridine ring can undergo metalation reactions where a metal atom replaces a hydrogen atom on the ring.
Cross-Coupling Reactions: The compound can undergo cross-coupling reactions with appropriate coupling partners to form biaryl compounds or other substituted pyridine derivatives.
Reduction Reactions: The halogens or the methyl group can be reduced to different oxidation states depending on the reducing agent used.
Oxidation Reactions: The compound can undergo oxidation reactions to convert the methyl group to a carboxylic acid or aldehyde group.
Grignard Reactions: The compound can react with Grignard reagents to form substituted pyridine derivatives.
Halogenation Reactions: The compound can undergo further halogenation reactions under appropriate conditions.
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5-Bromo-2-chloro-4-methyl-3-nitropyridine
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5-Bromo-2-chloro-4-methylnicotinic acid
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5-Bromo-2-chloro-4-methylnicotinonitrile
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5-Bromo-2-chloro-4-methylpyridin-3-amine