Chemistry Heterocyclic Building Blocks Pyrimidines 5-bromo-2-chloropyrimidine
Ambeed provide 6 derivatives of 5-bromo-2-chloropyrimidine.
These compounds have the same murcko framework: pyrimidine
Substitution reactions: The halogens (bromo and chloro) on the pyrimidine ring are susceptible to nucleophilic substitution reactions. For example, they can be replaced by nucleophiles such as amines, thiols, or other nucleophilic reagents.
Cross-coupling reactions: 5-bromo-2-chloro Pyrimidines can participate in Suzuki coupling reactions, where it reacts with aryl or vinyl boronic acids under the influence of a palladium catalyst to form biaryl or bivinyl compounds.
Metalation reactions: The halogen atoms can undergo metal-halogen exchange reactions with strong bases, resulting in the formation of metalated intermediates. These metalated intermediates can then react with various electrophiles.
Reductive reactions: The compound can undergo reductive amination reactions with amines in the presence of reducing agents, leading to the introduction of an amine group.
Cyclization reactions: Depending on the reaction conditions and the presence of suitable functional groups, 5-bromo-2-chloro Pyrimidines can undergo cyclization reactions to form fused ring systems or other cyclic structures.
Halogen-metal exchange reactions: The halogen atoms can be exchanged with metal atoms or metal-containing reagents under specific conditions, leading to the formation of organometallic compounds.
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5-Bromo-2-chloro-4-isopropoxypyrimidine
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5-Bromo-2,4-dichloro-6-(trifluoromethyl)pyrimidine
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5-Bromo-2-chloro-N-methylpyrimidin-4-amine
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5-Bromo-2-chloro-4-(methylthio)pyrimidine