Chemistry Heterocyclic Building Blocks Pyridines 5-bromo-2-methoxypyridine
Ambeed provide 29 derivatives of 5-bromo-2-methoxypyridine.
These compounds have the same murcko framework: 5-bromo-2-methoxypyridineNucleophilic substitution reactions: The bromine atom can be replaced by a variety of nucleophiles, such as amines, thiols, or cyanide ions, to yield different substituted products.
Palladium-catalyzed coupling reactions: The bromine atom can undergo cross-coupling reactions with various organometallic reagents (e.g., organoboron, organotin, or organosilane compounds) in the presence of a pyridine catalyst to form biaryl compounds.
Suzuki-Miyaura coupling: This reaction involves the coupling of an aryl halide (such as 5-bromo-2-methoxypyridine) with an organoboron compound in the presence of a palladium catalyst, base, and appropriate reaction conditions to form a biaryl product.
Heck reaction: 5-bromo-2-methoxypyridine can undergo a Heck reaction with alkenes or alkynes in the presence of a palladium catalyst and a base, leading to the formation of substituted pyridine derivatives.
Nucleophilic aromatic substitution (SNAr): The bromine atom can be substituted by various nucleophiles under appropriate reaction conditions to yield different substituted pyridine derivatives.
Reductive reactions: The bromine atom can be reduced to a variety of functional groups, such as an alkyl group or a hydrogen atom, using reducing agents like lithium aluminum hydride (LiAlH4) or hydrogen gas in the presence of a suitable catalyst.
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1-(5-Bromo-2-methoxypyridin-3-yl)ethanone
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5-Bromo-3-(difluoromethyl)-2-methoxypyridine
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5-Bromo-2-methoxy-4-methyl-3-nitropyridine
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5-Bromo-3-(bromomethyl)-2-methoxypyridine
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5-Bromo-2-methoxy-4-(trifluoromethyl)pyridine
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5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine
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(5-Bromo-2-methoxypyridin-4-yl)boronic acid
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tert-Butyl ((5-bromo-2-methoxypyridin-3-yl)methyl)carbamate