Chemistry Heterocyclic Building Blocks Pyridines 5-bromo-2-methylpyridine
Substitution Reactions: The bromine atom can undergo substitution reactions, where it can be replaced by other nucleophiles. For instance, it can undergo nucleophilic substitution reactions with strong nucleophiles like amines or thiolates to form corresponding substituted products.
Metalation Reactions: The pyridine ring can undergo metalation reactions with strong bases or metal reagents. For example, treatment with butyllithium or Grignard reagents can lead to the formation of organometallic compounds.
Cross-Coupling Reactions: The bromine atom can participate in cross-coupling reactions, such as Suzuki-Miyaura or Heck reactions, where it can be replaced by another organic group under palladium catalysis.
Redox Reactions: The bromine atom can undergo redox reactions. For instance, it can be involved in oxidation reactions to form bromopyridine derivatives.
Ring-closure Reactions: The pyridine ring can participate in ring-closure reactions, such as cyclization reactions with appropriate reagents, leading to the formation of heterocyclic compounds.
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3-Bromo-6-methyl-2-(trifluoromethyl)pyridine
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(5-Bromo-2-methylpyridin-3-yl)methanol
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1-(5-Bromo-2-methylpyridin-3-yl)ethanone
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5-Bromo-2-methyl-3-(trifluoromethyl)pyridine