Chemistry Heterocyclic Building Blocks Pyrimidines 5-bromo-2-methylpyrimidine
Ambeed provide 5 derivatives of 5-bromo-2-methylpyrimidine.
These compounds have the same murcko framework: pyrimidine
Nucleophilic Substitution: The bromine atom at the 5-position is a good leaving group, making the compound susceptible to nucleophilic substitution reactions.
Cross-Coupling Reactions: 5-bromo-2-methylPyrimidines can be used in cross-coupling reactions, such as Suzuki-Miyaura, Stille, or Heck reactions. These reactions involve coupling with another organic compound, often facilitated by a transition metal catalyst.
Metalation: The compound can undergo metalation reactions where a metal is introduced at a specific position.
Arylation: The bromine atom can be replaced by an aryl group through palladium-catalyzed arylation reactions.
Halogen-Metal Exchange: The bromine atom can undergo halogen-metal exchange reactions with certain metal-containing reagents, leading to the formation of metalated intermediates.
Alkylation: The compound can be alkylated at various positions, introducing alkyl groups at the 2-position or other positions.
Reductive Processes: Reduction reactions can be performed to convert the bromine substituent to other functional groups, such as an alkane or alkene.
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5-Bromo-2-methyl-4-(trifluoromethyl)pyrimidine
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2-Methyl-5-bromopyrimidine-4-carboxylic acid
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5-Bromo-4-chloro-2,6-dimethylpyrimidine