Chemistry Heterocyclic Building Blocks Pyrimidines 5-bromo-4-chloropyrimidine
Ambeed provide 4 derivatives of 5-bromo-4-chloropyrimidine.
These compounds have the same murcko framework: pyrimidine
Nucleophilic Substitution: The bromine and chlorine atoms on the pyrimidine ring can undergo nucleophilic substitution reactions. For example, reactions with a nucleophile like amines or thiols could replace the bromine or chlorine.
Suzuki-Miyaura Coupling: 5-bromo-4-chloro pyrimidine can participate in Suzuki-Miyaura coupling reactions with boronic acids or boronate esters, leading to the formation of biaryl compounds.
Stille Coupling: This reaction involves coupling with organotin compounds.
Metalation Reactions: The pyrimidine ring can undergo lithiation, creating a reactive intermediate that can be used for further reactions.
Reduction Reactions: The double bond in the pyrimidine ring may undergo hydrogenation, usually in the presence of a metal catalyst.
Functional Group Transformations: The bromo and chloro groups can be utilized for amidation reactions, leading to the formation of amides.
Halogenation: The bromo and chloro substituents may be further modified through halogenation reactions.
Heck Reaction: In the presence of a palladium catalyst, 5-bromo-4-chloro pyrimidines can undergo Heck coupling with olefins.
Sulfonation reactions: Introduction of sulfonate groups can be achieved using appropriate sulfonating agents.
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5-Bromo-4-chloro-6-(trifluoromethyl)pyrimidine