Chemistry Heterocyclic Building Blocks Pyridines 5-bromonicotinaldehyde
Ambeed provide 12 derivatives of 5-bromonicotinaldehyde.
These compounds have the same murcko framework: 5-bromonicotinaldehydeNucleophilic addition reactions: The aldehyde group can undergo nucleophilic addition reactions with nucleophiles such as Grignard reagents, organolithium compounds, or cyanide ions.
Reduction reactions: 5-Bromonicotinaldehyde can be reduced to its corresponding alcohol using reducing agents such as sodium borohydride or lithium aluminum hydride.
Substitution reactions: The bromine atom can undergo substitution reactions with various nucleophiles, such as amines, thiols, or cyanide ions, leading to the formation of substituted products.
Condensation reactions: 5-Bromonicotinaldehyde can undergo condensation reactions with amines or hydrazines to form imine or hydrazone derivatives, respectively.
Oxidation reactions: The aldehyde group can be further oxidized to a carboxylic acid using oxidizing agents such as potassium permanganate or chromic acid.
Cross-coupling reactions: 5-Bromonicotinaldehyde can participate in various cross-coupling reactions, such as Suzuki coupling or Stille coupling, with appropriate coupling partners.
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5-Bromo-4-methoxynicotinaldehyde
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5-Bromo-2-(difluoromethoxy)nicotinaldehyde