Chemistry Heterocyclic Building Blocks Pyridines 5-bromonicotinonitrile
Ambeed provide 6 derivatives of 5-bromonicotinonitrile.
These compounds have the same murcko framework: 5-bromonicotinonitrileSubstitution Reactions: The bromine atom can undergo substitution reactions, such as nucleophilic substitution, where the bromine atom is replaced by another nucleophile.
Nucleophilic Addition: The nitrile group can undergo nucleophilic addition reactions, where a nucleophile adds to the carbon atom of the nitrile group, leading to the formation of amines or carboxylic acids.
Transition Metal Complexation: The pyridine ring can coordinate with transition metals to form coordination complexes, which can have various applications in catalysis or material science.
Reduction Reactions: The nitrile group or the bromine atom can be reduced to other functional groups. For example, the nitrile group can be reduced to an amine, and the bromine atom can be replaced with a hydrogen atom.
Heterocyclic Chemistry: The pyridine ring can undergo various heterocyclic reactions, such as ring-closure reactions or condensation reactions with other functional groups.
Cross-Coupling Reactions: 5-Bromonicotinonitrile can participate in cross-coupling reactions, such as Suzuki coupling or Heck coupling, where it reacts with another organic substrate in the presence of a suitable catalyst to form a new carbon-carbon bond.
Electrophilic Aromatic Substitution (EAS): The pyridine ring can undergo EAS reactions where an electrophile substitutes for a hydrogen atom on the aromatic ring. This can lead to the introduction of various functional groups onto the aromatic ring.
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5-Bromo-2-(dimethylamino)nicotinonitrile