Chemistry Heterocyclic Building Blocks Pyridines 5-bromopyridin-2-amine
Ambeed provide 35 derivatives of 5-bromopyridin-2-amine.
These compounds have the same murcko framework: 5-bromopyridin-2-amineSubstitution Reactions: The bromine atom can undergo substitution reactions, where it is replaced by other nucleophiles. For example, nucleophilic substitution reactions with various nucleophiles such as amines, alcohols, or thiols can lead to the formation of substituted pyridine derivatives.
Reductive Amination: The amino group can undergo reductive amination reactions with aldehydes or ketones in the presence of reducing agents such as sodium cyanoborohydride or sodium triacetoxyborohydride, yielding secondary or tertiary amines, respectively.
Nucleophilic Aromatic Substitution (SNAr): The amino group can act as a nucleophile in SNAr reactions with electrophiles that are susceptible to substitution reactions on the aromatic ring, leading to the introduction of various functional groups.
Metalation Reactions: The pyridine ring can undergo metalation reactions, where a metal atom replaces a hydrogen atom on the aromatic ring, leading to the formation of metal complexes. These metal complexes can further participate in various catalytic or stoichiometric reactions.
Cross-Coupling Reactions: The bromine atom can participate in cross-coupling reactions, such as Suzuki, Stille, or Heck reactions, enabling the formation of biaryl or heteroaryl compounds by coupling with suitable organic substrates.
Oxidation Reactions: Both the amino group and the bromine atom can undergo oxidation reactions under appropriate conditions, leading to the formation of various oxidized products.
Amidation Reactions: The amino group can undergo amidation reactions with carboxylic acids or their derivatives, leading to the formation of amide compounds.
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4-(2-Amino-5-bromopyridin-3-yl)-2-methylbut-3-yn-2-ol
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Ethyl 3-(2-amino-5-bromopyridin-3-yl)acrylate
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Methyl 2-amino-5-bromo-4-pyridinecarboxylate
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5-Bromo-3-((trimethylsilyl)ethynyl)pyridin-2-amine
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2-Amino-5-bromo-4-chloro-3-nitropyridine
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Methyl 2-amino-5-bromopyridine-3-carboxylate
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5-Bromopyridine-2,3-diamine dihydrochloride
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2-Amino-5-bromo-3-(hydroxymethyl)pyridine
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5-Bromo-4-(trifluoromethyl)pyridin-2-amine
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5-Bromo-3-(difluoromethoxy)pyridin-2-amine