Chemistry Heterocyclic Building Blocks Pyridines 5-chloro-2-methoxypyridine
Ambeed provide 10 derivatives of 5-chloro-2-methoxypyridine.
These compounds have the same murcko framework: 5-chloro-2-methoxypyridineNucleophilic substitution: The chlorine atom can be substituted by a nucleophile, such as a hydroxide ion, amine, or thiol, to form a new compound with the nucleophile replacing the chlorine atom.
Electrophilic substitution: The electron-rich pyridine ring can undergo electrophilic aromatic substitution reactions, where an electrophile replaces the hydrogen atom on the ring. Common electrophiles include acyl halides, nitro groups, and alkylating agents.
Cross-coupling reactions: The chloro substituent can participate in various cross-coupling reactions, such as Suzuki, Stille, or Heck coupling, to form biaryl or heteroaryl compounds.
Oxidation reactions: The methoxy group can undergo oxidation to form the corresponding alcohol, aldehyde, or carboxylic acid, depending on the reaction conditions and oxidizing agent used.
Reduction reactions: Both the chloro and methoxy groups can undergo reduction reactions to form the corresponding substituted pyridine derivatives.
Cyclization reactions: The functional groups present in 5-chloro-2-methoxypyridine can participate in cyclization reactions under appropriate conditions to form cyclic compounds.
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(5-Chloro-2-methoxypyridin-3-yl)boronic acid
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(5-Chloro-2-methoxypyridin-3-yl)methanamine hydrochloride
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(5-Chloro-2-methoxypyridin-4-yl)boronic acid
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5-Chloro-3-(chloromethyl)-2-methoxypyridine