Chemistry Heterocyclic Building Blocks Pyridines 5-chloropicolinonitrile
Ambeed provide 6 derivatives of 5-chloropicolinonitrile.
These compounds have the same murcko framework: 5-chloropicolinonitrileSubstitution Reactions: The chloro group (-Cl) can undergo substitution reactions with various nucleophiles (e.g., amines, hydroxide ions, etc.) to form substituted products.
Nucleophilic Addition Reactions: The cyano group (-CN) can undergo nucleophilic addition reactions with nucleophiles or electrophiles, leading to the formation of new carbon-carbon or carbon-heteroatom bonds.
Reduction Reactions: The cyano group (-CN) can be reduced to form primary amines using reducing agents such as lithium aluminum hydride (LiAlH4) or hydrogen gas (H2) in the presence of a catalyst.
Grignard Reactions: 5-Chloropicolinonitrile can react with organomagnesium compounds (Grignard reagents) to form substituted pyridine derivatives.
Metalation Reactions: The pyridine ring can undergo metalation reactions with strong bases and transition metal complexes, leading to the formation of metalated intermediates that can further react with electrophiles or nucleophiles.
Cross-Coupling Reactions: 5-Chloropicolinonitrile can undergo cross-coupling reactions, such as Suzuki, Heck, or Sonogashira coupling, to form biaryl or alkyl-aryl compounds.
Heterocyclic Chemistry: The presence of the pyridine ring makes 5-chloropicolinonitrile useful in heterocyclic chemistry, where it can participate in various cyclization reactions to form fused or spiro heterocycles.
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5-Chloro-3-(methoxymethyl)picolinonitrile
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5-Chloro-4-(trifluoromethyl)picolinonitrile