Chemistry Heterocyclic Building Blocks Pyridines 5-chloropyridin-2-amine
Ambeed provide 26 derivatives of 5-chloropyridin-2-amine.
These compounds have the same murcko framework: 5-chloropyridin-2-amineNucleophilic substitution: The amino group can undergo substitution reactions with electrophiles to form various substituted products.
Suzuki coupling: The chloro group can undergo cross-coupling reactions with boronic acids or boron esters in the presence of a palladium catalyst to form biaryl compounds.
Reductive amination: The amine group can undergo reactions with carbonyl compounds in the presence of reducing agents to form secondary or tertiary amines.
N-alkylation: The amine group can undergo alkylation reactions with alkyl halides or alkyl sulfonates to form N-alkylated products.
Cyclization: The amine and chloro groups can participate in cyclization reactions under suitable conditions to form heterocyclic compounds.
Oxidation: The amine group can be oxidized to form corresponding nitro compounds or other oxidized products.
Acylation: The amine group can undergo acylation reactions with acyl chlorides or acid anhydrides to form amides.
Reduction: The chloro group can be reduced to the corresponding methyl group using reducing agents like lithium aluminum hydride (LiAlH4) or hydrogenation catalysts.
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2-Amino-5-chloropyridine-3-carboxylic acid
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5-Chloro-3-(trifluoromethyl)pyridin-2-amine
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2-Amino-5-chloro-4-methylnicotinonitrile
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5-Chloro-4-(trifluoromethyl)pyridin-2-amine
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5-Chloro-4-(trifluoromethyl)pyridin-2-amine hydrochloride
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5-Chloro-3-((trimethylsilyl)ethynyl)pyridin-2-amine
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5-Chloro-4-(difluoromethoxy)pyridin-2-amine