Chemistry Heterocyclic Building Blocks Pyridines 5-chloropyridin-3-amine
Ambeed provide 7 derivatives of 5-chloropyridin-3-amine.
These compounds have the same murcko framework: 5-chloropyridin-3-amineSubstitution Reactions: The chlorine atom in the 5-position of the pyridine ring can undergo substitution reactions with various nucleophiles. For example, it can be replaced by a hydroxyl group in the presence of a base to form a hydroxy-substituted pyridine derivative.
Nucleophilic Addition Reactions: The amine group can undergo nucleophilic addition reactions with electrophiles. For instance, it can react with alkyl halides to form N-alkylated or N,N-dialkylated products.
Reduction Reactions: The amine group can be reduced to form secondary or tertiary amines, or even converted to an amine with fewer alkyl substituents.
Condensation Reactions: The amine group can participate in condensation reactions with carbonyl compounds, leading to the formation of imines or enamines.
Arylation Reactions: The pyridine ring can undergo arylation reactions, where an aryl group is introduced onto the ring. This can be achieved through transition metal-catalyzed cross-coupling reactions.
Oxidation Reactions: Both the amine group and the chlorine atom can be oxidized under appropriate conditions to yield different functional groups.
Heterocyclization Reactions: The compound can participate in heterocyclization reactions, where it forms a cyclic compound containing heteroatoms such as nitrogen, oxygen, or sulfur.
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