Chemistry Heterocyclic Building Blocks Pyridines 5-fluoro-2-methoxypyridine
Ambeed provide 15 derivatives of 5-fluoro-2-methoxypyridine.
These compounds have the same murcko framework: 5-fluoro-2-methoxypyridineNucleophilic substitution reactions: The fluorine atom in 5-fluoro-2-methoxypyridine can be replaced by nucleophiles in substitution reactions. For example, nucleophilic aromatic substitution (SNAr) reactions can occur where the fluorine atom is replaced by a nucleophile such as a hydroxide ion or an amine.
Electrophilic aromatic substitution reactions: The pyridine ring in 5-fluoro-2-methoxypyridine can undergo electrophilic aromatic substitution reactions where electrophiles attack the aromatic ring. For example, reactions with electrophiles like acyl chlorides or nitro groups can occur.
Nucleophilic addition reactions: The methoxy group in 5-fluoro-2-methoxypyridine can undergo nucleophilic addition reactions with electrophiles. For instance, the methoxy group can react with electrophiles such as carbonyl compounds in nucleophilic addition reactions.
Redox reactions: 5-Fluoro-2-methoxypyridine can participate in redox reactions where the fluorine atom or the methoxy group may undergo oxidation or reduction under appropriate conditions.
Metal-catalyzed reactions: Metal-catalyzed reactions such as pyridine-catalyzed cross-coupling reactions can occur with 5-fluoro-2-methoxypyridine, enabling the synthesis of various substituted pyridine derivatives.
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(5-Fluoro-2-methoxypyridin-3-yl)methanol
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5-Fluoro-2-methoxypyridine-4-boronic acid
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(5-Fluoro-2-methoxypyridin-3-yl)boronic acid
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(R)-1-(5-fluoro-2-methoxypyridin-3-yl)ethan-1-amine
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5-Fluoro-2-methoxypyridine-3-carboxaldehyde