Chemistry Heterocyclic Building Blocks Pyridines 5-fluoro-2-methylpyridine
Ambeed provide 8 derivatives of 5-fluoro-2-methylpyridine.
These compounds have the same murcko framework: 5-fluoro-2-methylpyridineNucleophilic Substitution: The fluorine atom can be substituted by a nucleophile, such as hydroxide ion, to form 5-hydroxy-2-methylpyridine.
Electrophilic Aromatic Substitution: The electron-rich aromatic ring can undergo substitution reactions with electrophiles. For example, it can react with strong electrophiles like nitronium ion to form nitro-substituted pyridines.
Metalation: The methyl group can be deprotonated by strong bases like organolithium or Grignard reagents to form a metalated intermediate which can subsequently react with electrophiles.
Oxidation: The methyl group can be oxidized under appropriate conditions to form corresponding carboxylic acid or ketone.
Reduction: The fluorine atom or the pyridine ring can be reduced under appropriate conditions, depending on the reagents and reaction conditions employed.
Alkylation/Acylation: The pyridine ring can undergo alkylation or acylation reactions under suitable conditions.
Heterocyclic Chemistry: It can participate in various heterocyclic synthesis reactions due to its pyridine ring.
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5-Fluoro-2-methyl-3-nitropyridine
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5-Fluoro-2-methylisonicotinic acid