Chemistry Heterocyclic Building Blocks Pyridines 5-fluoropyridin-2-amine
Ambeed provide 15 derivatives of 5-fluoropyridin-2-amine.
These compounds have the same murcko framework: 5-fluoropyridin-2-amineNucleophilic substitution: The amino group (-NH2) in 5-chloropyridin-2-amine can undergo nucleophilic substitution reactions with electrophiles, such as alkyl halides or acyl halides, leading to the formation of substituted products.
Suzuki coupling: 5-chloropyridin-2-amine can participate in Suzuki coupling reactions, where it reacts with aryl or vinyl boronic acids or esters in the presence of a palladium catalyst to form biaryl or bivinyl compounds.
Reductive amination: The amine group in 5-chloropyridin-2-amine can undergo reductive amination reactions with carbonyl compounds (aldehydes or ketones) in the presence of a reducing agent to form secondary or tertiary amines.
Amide formation: The amine group can react with carboxylic acids or their derivatives (e.g., acid chlorides, acid anhydrides) to form amides.
Heterocyclic synthesis: 5-chloropyridin-2-amine can undergo various heterocyclic synthesis reactions, such as cyclization reactions with appropriate reagents to form fused or spiro heterocyclic compounds.
Oxidation reactions: The amino group can be oxidized to the corresponding nitro group using suitable oxidizing agents.
Halogenation reactions: The chlorine atom in 5-chloropyridin-2-amine can undergo substitution reactions with other halogens or functional groups under appropriate conditions.
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