Chemistry Heterocyclic Building Blocks Pyridines 5-iodopyridin-2-amine
Ambeed provide 17 derivatives of 5-iodopyridin-2-amine.
These compounds have the same murcko framework: 5-iodopyridin-2-amineSubstitution Reactions: The iodine atom can undergo substitution reactions with various nucleophiles such as amines, alcohols, thiols, etc., leading to the formation of substituted products.
Metalation Reactions: The amino group can coordinate with metal ions, leading to metalation reactions. This can further facilitate various synthetic transformations.
Cross-Coupling Reactions: The iodine atom can participate in cross-coupling reactions, such as Suzuki, Stille, or Heck reactions, where it couples with another organic halide or pseudohalide in the presence of suitable catalysts.
Reductive Reactions: The iodine atom can undergo reductive transformations under appropriate conditions, leading to the formation of products with reduced iodine content.
Nucleophilic Aromatic Substitution (SNAr): The amino group can act as a nucleophile in SNAr reactions, displacing the iodine atom and leading to the formation of various substituted products.
Functional Group Transformations: The amino group can undergo various functional group transformations such as acylation, alkylation, and formylation, leading to the introduction of new functional groups at the amino position.
Cyclization Reactions: Depending on the structure and conditions, cyclization reactions involving the amino group and adjacent functional groups can occur, leading to the formation of cyclic compounds.
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2-Amino-5-iodo-4-methylnicotinonitrile
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5-Iodo-3-(trifluoromethyl)pyridin-2-amine