Chemistry Heterocyclic Building Blocks Pyridines 5-iodopyridin-2-ol
Ambeed provide 8 derivatives of 5-iodopyridin-2-ol.
These compounds have the same murcko framework: 5-iodopyridin-2-olSubstitution Reactions: The iodine atom is relatively reactive and can undergo substitution reactions. For instance, it can be replaced by other nucleophiles such as amines or thiols.
Oxidation: The hydroxyl group can be oxidized to a carbonyl group (aldehyde or ketone) using oxidizing agents like chromic acid or Jones reagent.
Esterification: The hydroxyl group can react with carboxylic acids or acyl chlorides to form esters under suitable conditions.
Reduction: The iodine atom can be reduced to iodide, typically using reducing agents like sodium borohydride or hydrogen gas over a catalyst.
Ring Closure Reactions: Depending on the conditions and reagents, the compound can undergo ring closure reactions to form cyclic compounds.
Metal Complexation: The compound can coordinate with transition metals via both the iodine atom and the hydroxyl group, leading to the formation of metal complexes.
Halogenation: The aromatic ring can undergo further halogenation reactions under specific conditions, introducing additional halogen atoms onto the ring.
Nitration: The aromatic ring can undergo nitration reactions with nitric acid and sulfuric acid mixture to introduce a nitro group.
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