Chemistry Heterocyclic Building Blocks Pyridines 5-nitronicotinic acid
Ambeed provide 5 derivatives of 5-nitronicotinic acid.
These compounds have the same murcko framework: 5-nitronicotinic acidNitration: The nitro group on the aromatic ring is susceptible to further nitration under appropriate conditions, leading to the introduction of another nitro group. This can be achieved using nitrating agents like nitric acid or a mixture of nitric and sulfuric acid.
Reduction: The nitro group (-NO2) can be reduced to an amino group (-NH2) under suitable conditions. Common reducing agents include iron and hydrochloric acid (Fe/HCl), tin and hydrochloric acid (Sn/HCl), or catalytic hydrogenation.
Acid-Base Reactions: The carboxylic acid group can undergo typical acid-base reactions. For instance, it can react with bases to form salts, or it can undergo esterification or amidation reactions.
Substitution Reactions: The nitro group can undergo substitution reactions, especially under harsh conditions or with appropriate nucleophiles. For instance, it can undergo nucleophilic aromatic substitution reactions.
Decarboxylation: Under certain conditions, carboxylic acids can undergo decarboxylation, resulting in the loss of carbon dioxide and the formation of a substituted aromatic compound.
Coupling Reactions: The aromatic ring can participate in coupling reactions, such as Suzuki coupling or Heck coupling, to form biaryl compounds.
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2-Methyl-5-nitro-3-pyridinecarboxylic acid