Chemistry Heterocyclic Building Blocks Pyridines 5-nitropyridin-2-amine
Ambeed provide 6 derivatives of 5-nitropyridin-2-amine.
These compounds have the same murcko framework: 5-nitropyridin-2-amineNucleophilic substitution: The amino group can undergo nucleophilic substitution reactions, where the amino group acts as a nucleophile, replacing other functional groups. For example, it can react with alkyl halides to form substituted amines.
Reduction: The nitro group can be reduced to an amino group under appropriate conditions. Common reducing agents include hydrogen gas in the presence of a catalyst (such as palladium or platinum), tin(II) chloride, or iron filings with acid.
Aromatic substitution: The pyridine ring can undergo electrophilic aromatic substitution reactions. For instance, it can react with strong electrophiles such as acyl chlorides or nitration reagents to form substituted products.
Acid-base reactions: The amino group can act as a base, accepting a proton (H+) to form the corresponding ammonium ion. Conversely, the nitro group can act as an acid in certain conditions.
Metal complexation: The amino and nitro groups can coordinate with metal ions to form metal complexes. This property can be utilized in various applications, including coordination chemistry and catalysis.
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