Chemistry Heterocyclic Building Blocks Pyrimidines 5-phenylpyrimidine
Ambeed provide 16 derivatives of 5-phenylpyrimidine.
These compounds have the same murcko framework: 5-phenylpyrimidine.
Aromatic Electrophilic Substitution: The phenyl group in 5-phenylpyrimidine can undergo electrophilic aromatic substitution reactions. For example, it can react with strong electrophiles like nitronium ions (NO2+), acyl halides, or alkyl halides to introduce various substituents onto the phenyl ring.
Nucleophilic Substitution: If the pyrimidine ring contains a suitable leaving group (e.g., halide or tosylate), it can undergo nucleophilic substitution reactions with nucleophiles.
Reductive Amination: 5-Phenylpyrimidine can undergo reductive amination reactions with primary amines in the presence of reducing agents like sodium cyanoborohydride to form secondary or tertiary amines.
Oxidation: The compound can undergo oxidation reactions under appropriate conditions, leading to the formation of oxidized derivatives. The specific products will depend on the oxidizing agents used.
Alkylation/Acylation: The pyrimidine nitrogen atoms can act as nucleophiles and undergo alkylation or acylation reactions with suitable alkyl or acyl halides.
Reduction: The compound can be reduced with reducing agents to form derivatives with reduced functional groups.
Cross-Coupling Reactions: Depending on the available functional groups, 5-phenylpyrimidine can participate in various cross-coupling reactions, such as Suzuki-Miyaura, Heck, or Stille reactions, to form biaryl or other coupled products.
Framework+−
By Key Group+−
By Parent Nucleus+−
By Functional Group+−
Formula Weight+−
Deals click to sign in and save
5-(4-Bromophenyl)-6-hydroxypyrimidin-4(1H)-one
Deals click to sign in and save
5-(4-Bromophenyl)-4,6-dichloropyrimidine
click to sign in and save
N-(5-(4-Bromophenyl)-6-(2-hydroxyethoxy)pyrimidin-4-yl)propane-1-sulfamide
click to sign in and save
N-[5-(4-Bromophenyl)-6-chloro-4-pyrimidinyl]-N'-propylsulfamide