Chemistry Heterocyclic Building Blocks Pyridines 6,7-dihydro-5H-cyclopenta[c]pyridine
Ambeed provide 7 derivatives of 6,7-dihydro-5H-cyclopenta[c]pyridine.
These compounds have the same murcko framework: 6,7-dihydro-5H-cyclopenta[c]pyridine.
Aromatic Substitution: Depending on the substituents attached to the cyclopentane and pyridine rings, 6,7-dihydro-5H-cyclopenta[c]pyridine can undergo electrophilic aromatic substitution reactions. For example, you can introduce new substituents through reactions like Friedel-Crafts acylation or alkylation.
Oxidation: The cyclopentane ring in the compound can be oxidized under certain conditions. Oxidation reactions may introduce oxygen-containing functional groups, such as ketones or aldehydes.
Reduction: The compound can be reduced to form saturated cyclopentane derivatives, depending on the reaction conditions and the choice of reducing agents.
Nucleophilic Substitution: If there are suitable leaving groups on the compound, nucleophilic substitution reactions can occur. This may involve the replacement of a leaving group with a nucleophile, leading to the formation of different compounds.
Ring Opening: Depending on the reaction conditions and the presence of functional groups, ring-opening reactions of the cyclopentane ring can occur. This might lead to the formation of open-chain compounds.
Cyclization: Under appropriate conditions and with suitable reagents, 6,7-dihydro-5H-cyclopenta[c]pyridine can participate in cyclization reactions to form more complex cyclic compounds.
Functional Group Transformations: The compound can undergo various functional group transformations, such as halogenation, hydroxylation, and amination, depending on the specific functional groups present.
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3-Chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile
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3-Isopropyl-1-methoxy-6,7-dihydro-5H-cyclopenta[c]pyridin-4-amine
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3-Isopropyl-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carboxamide
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1-Bromo-3-isopropyl-6,7-dihydro-5H-cyclopenta[c]pyridin-4-amine
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3-Isopropyl-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile
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3-(Prop-1-en-2-yl)-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile
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3-Isopropyl-6,7-dihydro-5H-cyclopenta[c]pyridin-4-amine