Chemistry Heterocyclic Building Blocks Pyrimidines 6,7-dihydro-5H-cyclopenta[d]pyrimidine
Ambeed provide 5 derivatives of 6,7-dihydro-5H-cyclopenta[d]pyrimidine.
These compounds have the same murcko framework: 6,7-dihydro-5H-cyclopenta[d]pyrimidine.
Aromatization: If the compound has double bonds in the ring system and is not fully aromatic, it can undergo aromatization reactions to become fully aromatic. This can involve treatment with various reagents like strong acids or bases to form an aromatic system.
Substitution Reactions: Depending on the substituents present on the cyclopenta[d]pyrimidine ring, it can undergo electrophilic aromatic substitution or nucleophilic substitution reactions. For example, you can substitute a halogen atom or other groups onto the ring using appropriate reagents and conditions.
Reduction: Reduction reactions can convert the double bonds in the ring to single bonds. This can be achieved using reducing agents like hydrogen gas and a metal catalyst or chemical reducing agents.
Oxidation: If the compound contains reducing groups, it can undergo oxidation reactions. Common oxidizing agents like potassium permanganate or chromium(VI) reagents can be used.
Functional Group Transformations: Depending on the functional groups present, various transformations can occur. For instance, if there are ketones or aldehydes, they can be converted to alcohols or other functional groups using appropriate reagents.
Ring Opening: Under specific conditions, the cyclopenta[d]pyrimidine ring can undergo ring-opening reactions to form open-chain compounds. This might involve the use of strong acids or bases.
Cyclization Reactions: It can also participate in intramolecular cyclization reactions if suitable functional groups are present in the molecule.
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2-Chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine
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2-Chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine
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4-Chloro-2-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine
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6,7-Dihydro-5H-cyclopenta[d]pyrimidin-4-amine
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2,4-Dichloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine