Chemistry Heterocyclic Building Blocks Pyridines 6-(trifluoromethyl)pyridin-2-amine
Ambeed provide 11 derivatives of 6-(trifluoromethyl)pyridin-2-amine.
These compounds have the same murcko framework: 6-(trifluoromethyl)pyridin-2-amineSubstitution Reactions: The amino group and the fluorine atoms are potential sites for substitution reactions. These reactions can involve electrophilic aromatic substitution, nucleophilic aromatic substitution, or metal-catalyzed cross-coupling reactions.
Acylation and Alkylation: The amino group can undergo acylation or alkylation reactions to introduce various functional groups.
Condensation Reactions: It can undergo condensation reactions with carbonyl compounds to form imines or with aldehydes to form Schiff bases.
Reduction Reactions: The nitro group can be reduced to the corresponding amine group using reducing agents such as hydrogen gas over a metal catalyst or with a reducing agent like tin(II) chloride.
Oxidation Reactions: The amine group can be oxidized to form amine oxides or further oxidized to nitriles or other oxidation products.
Heterocyclic Synthesis: It can participate in heterocyclic synthesis, especially involving pyridine ring transformations.
Protonation and Basic Reactions: The amino group can be protonated under acidic conditions or involved in basic reactions.
Metal Complexation: The nitrogen atom in the pyridine ring can coordinate with transition metals to form metal complexes.
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6-Amino-2-(trifluoromethyl)pyridin-3-ol
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3-Methoxy-6-(trifluoromethyl)pyridin-2-amine
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3-Methyl-6-(trifluoromethyl)pyridin-2-amine
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3-(Prop-1-en-2-yl)-6-(trifluoromethyl)pyridin-2-amine
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5-Chloro-6-(trifluoromethyl)pyridin-2-amine
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3-Isopropyl-6-(trifluoromethyl)pyridin-2-amine
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6-(Trifluoromethyl)pyridine-2,3-diamine
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5-Bromo-6-trifluoromethylpyridin-2-ylamine