Chemistry
Heterocyclic Building Blocks
Pyridines
6-(trifluoromethyl)pyridin-3-amine
Nucleophilic substitution reactions: The amine group can act as a nucleophile and undergo substitution reactions with electrophiles. For example, it can react with alkyl halides to form alkyl-substituted amines.
Acylation reactions: The amine group can undergo acylation reactions, where it reacts with acyl halides or acid anhydrides to form amides.
Nucleophilic aromatic substitution (SNAr): The presence of the electron-withdrawing trifluoromethyl group can activate the aromatic ring towards nucleophilic attack. This can lead to substitution reactions at the 6th position of the pyridine ring.
Reductive amination: The amine group can undergo reductive amination reactions with carbonyl compounds, forming secondary or tertiary amines.
Metal-catalyzed reactions: The trifluoromethyl group can participate in various metal-catalyzed transformations, such as cross-coupling reactions or metal-mediated functionalization of the aromatic ring.
Oxidation reactions: The amine group can undergo oxidation to form various products, including imines, nitriles, or oximes.
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3-Amino-2-methyl-6-(trifluoromethyl)pyridine
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5-Amino-2-(trifluoromethyl)pyridin-4-ol
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Methyl 3-amino-6-(trifluoromethyl)picolinate