Chemistry Heterocyclic Building Blocks Quinolines 7,8-dihydroquinolin-5(6H)-one
Aromatic Substitution: The compound contains an aromatic ring, and it can undergo electrophilic aromatic substitution reactions. For example, it can react with strong electrophiles like nitronium ion (NO2+) or acyl chloride reagents to introduce substituents onto the aromatic ring.
Nucleophilic Addition: The carbonyl group (C=O) in the compound can undergo nucleophilic addition reactions with nucleophiles like amines or hydride sources, leading to the formation of different products.
Reduction: The carbonyl group can be reduced to the corresponding alcohol using reducing agents such as lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Oxidation: 7,8-dihydroquinolin-5(6H)-one can be oxidized to form compounds with a carbonyl group. Common oxidizing agents like potassium permanganate (KMnO4) or Jones reagent can be used for this purpose.
Ring Opening: The ring can be opened under certain conditions to produce open-chain compounds. For instance, the ring can be cleaved under acidic or basic conditions, depending on the reaction conditions.
Alkylation/Acylation: The compound can undergo alkylation or acylation reactions, typically at the nitrogen atom or at the oxygen atom of the carbonyl group. This can be achieved using alkyl halides or acyl chlorides, along with appropriate bases or catalysts.
Rearrangements: Depending on the reaction conditions and reagents, the compound may undergo various rearrangement reactions, leading to the formation of structurally different compounds.
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6-Bromo-5-methyl[1,2,4]triazolo[1,5-a]pyridine
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6-bromo-8-methoxy-[1,2,4]triazolo[1,5-a]pyridine
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Methyl 6-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylate
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6-Bromo-8-methyl-[1,2,4]triazolo[1,5-a]pyridine
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6-Bromo-8-fluoro-[1,2,4]triazolo[1,5-a]pyridine
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6-Bromo-7-methyl[1,2,4]triazolo[1,5-a]pyridine
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Ethyl 6-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-carboxylate
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Methyl 6-bromo-[1,2,4]triazolo[1,5-a]pyridine-8-carboxylate
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6-Bromo-2-methyl-[1,2,4]triazolo[1,5-a]pyridine
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6-Bromo-2-methyl-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridine
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6-Bromo-2,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridine