Chemistry Heterocyclic Building Blocks Indazoles 6-bromo-1H-indazole

6-bromo-1H-indazole

Ambeed provide 23 derivatives of 6-bromo-1H-indazole.

These compounds have the same murcko framework: 6-bromo-1H-indazole

Substitution Reactions: The bromine atom can undergo nucleophilic substitution reactions, such as displacement by a nucleophile, leading to the formation of various substituted indazoles.
Metalation: The indazole ring can undergo metalation reactions with strong bases, leading to the formation of organometallic compounds.
Cross-Coupling Reactions: The bromine atom can participate in palladium-catalyzed cross-coupling reactions, such as Suzuki coupling or Heck reaction, to introduce diverse substituents onto the indazole ring.
Reduction: The bromine atom can be reduced to a bromide ion or replaced by a hydrogen atom under appropriate conditions, leading to the formation of a reduced product.
Grignard Reaction: The indazole ring can react with a Grignard reagent to form a new carbon-carbon bond, leading to the introduction of various functional groups.
Nucleophilic Aromatic Substitution: The bromine atom can undergo nucleophilic aromatic substitution reactions with strong nucleophiles, leading to substitution of the bromine atom by the nucleophile.
Halogenation: The indazole ring can undergo halogenation reactions, such as bromination or chlorination, under appropriate conditions to introduce halogen substituents.
Cyclization Reactions: Depending on the reaction conditions, 6-bromo-1H-indazole can participate in cyclization reactions to form fused or spirocyclic compounds.

Further Reading:
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Purity
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  • 90%
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Conditions to empty

Framework+−

(1H-indazol-4-yl)boronic acid (1H-indazol-6-yl)boronic acid 1-(1H-indazol-1-yl)ethan-1-one 1-(tetrahydro-2H-pyran-2-yl)-1H-indazole 1-benzyl-1H-indazole 1-ethyl-1H-indazole 1H-indazol-3-amine 1H-indazol-3-ol 1H-indazol-4-amine 1H-indazol-4-ol 1H-indazol-5-amine 1H-indazol-6-amine 1H-indazol-6-ol 1H-indazol-7-amine 1H-indazole-3-carbaldehyde 1H-indazole-3-carbonitrile 1H-indazole-3-carboxylic acid 1H-indazole-4-carboxylic acid 1H-indazole-5-carboxylic acid 1H-indazole-7-carboxylic acid 2,3-dimethyl-2H-indazole 2-methyl-2H-indazole 3-(piperidin-4-yl)-1H-indazole 3-chloro-1H-indazole 4,5,6,7-tetrahydro-1H-indazole 4-chloro-1H-indazole 4-fluoro-1H-indazole 4-methoxy-1H-indazole 4-methyl-1H-indazole 4-nitro-1H-indazole 5-bromo-1H-indazole 5-chloro-1H-indazole 5-methoxy-1H-indazole 5-nitro-1H-indazole 6-(trifluoromethyl)-1H-indazole 6-bromo-1H-indazole 6-chloro-1H-indazole 6-fluoro-1H-indazole 6-methoxy-1H-indazole 6-methyl-1H-indazole 6-nitro-1H-indazole 7-bromo-1H-indazole 7-chloro-1H-indazole 7-fluoro-1H-indazole 7-methoxy-1H-indazole 7-nitro-1H-indazole methyl 1H-indazole-3-carboxylate methyl 1H-indazole-4-carboxylate methyl 1H-indazole-5-carboxylate methyl 1H-indazole-6-carboxylate methyl 1H-indazole-7-carboxylate methyl 2-methyl-2H-indazole-3-carboxylate tert-butyl 1H-indazole-1-carboxylate

By Key Group+−

amino-indazole amino-indazole-carboxylate bromo-ethyl-indazole bromo-fluoro-indazole bromo-indazol-amine bromo-indazole bromo-indazole-carboxylate bromo-methoxy-indazole bromo-nitro-indazole bromoindazole-carboxylic-acid bromoisopropyl-indazole bromomethyl-indazole chlorindazole-carboxylic acid chloro-indazole chloro-indazole-amine chloro-indazole-carboxylate chloro-methyl-indazole dimethyl-indazole dioxaborolan-indazole dioxaborolane-indazole-carboxylate fluoro-indazol-amine fluoro-indazole-carboxylate fluoro-indazole-carboxylic acid fluoro-methyl-indazole indazo-piperazine indazol-amide indazol-amine indazol-boronic acid indazol-one Indazole Derivatives indazole-benzene indazole-carbonitrile indazole-carboxylate indazole-carboxylic acid indazole-hydrochloride indazole-hydroxyl indazole-methanol iodo-indazol-amine iodo-indazole iodo-indazole-carboxylate iodomethyl-indazole methoxy-indazole-carboxylate methoxyindazole-carboxylic acid methyl-indazol-amine methyl-indazolamide methyl-indazole-carboxylic-acid methyl-nitro-indazole methylindazole nitro-indazol-amine tetrahydropyran-indazole trifluoromethyl-indazole

By Parent Nucleus+−

Aliphatic Heterocycles Aromatic Heterocycles Imidazoles Other Aliphatic Heterocycles Other Aromatic Heterocycles Piperazines Piperidines Pyrazoles Pyridines Pyrimidines Pyrrolidines Tetrahydropyrans

By Functional Group+−

Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkyls Alkynyls Amides Amines Aryls Benzyl bromides Bromides Carboxylic Acids Chiral Building Blocks Chlorides Esters Ethers Fluorinated Building Blocks Iodides Ketones Nitriles Nitroes Organoboron Oximes Phenols Phosphoruses Sulfamides Sulfides Sulfonates Sulfonic Acids Trifluoromethyls

By Chemical Elements+−

    Bx
    Cx
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    Ox
    Fx
    Six
    Px
    Sx
    Clx
    Brx
    Ix

    Formula Weight+−

    cLogP+−

    H-Acceptors+−

    H-Donors+−

    Polar Surface Area+−

    Druglikeness+−

    NNCH/NNH+−

    sp3-Atoms+−

    Non-Aromatic Rings+−

    Aromatic Rings+−

    Rotatable Bonds+−

    By Configuration+−

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