Chemistry Heterocyclic Building Blocks Pyridines 6-bromonicotinaldehyde
Ambeed provide 10 derivatives of 6-bromonicotinaldehyde.
These compounds have the same murcko framework: 6-bromonicotinaldehydeNucleophilic Substitution: The bromine atom is susceptible to nucleophilic substitution reactions, where a nucleophile replaces the bromine atom. This can lead to the formation of various products depending on the nature of the nucleophile and reaction conditions.
Aldol Condensation: The aldehyde group in 6-bromonicotinaldehyde can undergo aldol condensation reactions with suitable reactants, leading to the formation of β-hydroxy aldehydes.
Grignard Reaction: 6-Bromonicotinaldehyde can react with Grignard reagents to form alcohol derivatives. The bromine atom is replaced by the alkyl or aryl group from the Grignard reagent.
Reduction: The aldehyde group can be reduced to the corresponding alcohol using reducing agents such as sodium borohydride or lithium aluminum hydride.
Oxidation: The aldehyde group can be oxidized to the corresponding carboxylic acid using oxidizing agents such as potassium permanganate or chromic acid.
Halogenation: 6-Bromonicotinaldehyde can undergo further halogenation reactions under suitable conditions, where the bromine atom can be replaced with other halogen atoms.
Cross-Coupling Reactions: The bromine atom can participate in cross-coupling reactions with suitable coupling partners, such as organometallic compounds, to form biaryl or heteroaryl derivatives.
Heterocyclization: The presence of the nitrogen atom in the nicotinaldehyde moiety allows for heterocyclization reactions, leading to the formation of various heterocyclic compounds.
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tert-Butyl (2-bromo-5-formylpyridin-4-yl)carbamate