Chemistry Heterocyclic Building Blocks Pyridines 6-bromonicotinic acid
Ambeed provide 9 derivatives of 6-bromonicotinic acid.
These compounds have the same murcko framework: 6-bromonicotinic acidSubstitution Reactions: Being a halogenated compound, 6-bromonicotinic acid can undergo substitution reactions. For instance, it can undergo nucleophilic substitution reactions with strong nucleophiles, where the bromine atom is replaced by the incoming nucleophile.
Esterification: 6-bromonicotinic acid can undergo esterification reactions with alcohols in the presence of acid catalysts, yielding the corresponding esters .
Aromatic Substitution: The aromatic ring of 6-bromonicotinic acid can undergo electrophilic aromatic substitution reactions, where a substituent is added to the ring.
Metalation: The carboxylic acid group can be deprotonated by strong bases to form metal salts or complexes. This can be useful in various synthetic transformations.
Cross-Coupling Reactions: 6-bromonicotinic acid can participate in cross-coupling reactions such as Suzuki coupling, Stille coupling, or Heck coupling, where it reacts with appropriate partner compounds to form new carbon-carbon or carbon-heteroatom bonds.
Oxidation/Reduction: The functional groups present in 6-bromonicotinic acid can undergo oxidation or reduction reactions under appropriate conditions.
Amide Formation: It can react with amines to form amides, either through direct condensation reactions or via activation of the carboxylic acid group.
Halogenation: It can undergo further halogenation reactions if appropriate conditions and reagents are used.
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6-Bromo-2-(difluoromethyl)nicotinic acid