Chemistry Heterocyclic Building Blocks Pyridines 6-bromonicotinonitrile
Ambeed provide 7 derivatives of 6-bromonicotinonitrile.
These compounds have the same murcko framework: 6-bromonicotinonitrileNucleophilic Substitution: The bromine atom can be substituted by a nucleophile (e.g., hydroxide ion, thiolate ion, etc.) to form a new compound.
Grignard Reaction: 6-Bromonicotinonitrile can react with a Grignard reagent to form a new compound through nucleophilic addition.
Reduction: The nitrile group can be reduced to primary amine using reducing agents such as lithium aluminum hydride (LiAlH4) or catalytic hydrogenation.
Palladium-Catalyzed Coupling Reactions: It can participate in palladium-catalyzed cross-coupling reactions like Suzuki coupling, Stille coupling, or Heck reaction to form biaryl compounds or other coupled products.
Halogenation: The bromine atom can undergo further halogenation reactions under appropriate conditions, such as bromination or halogen exchange reactions.
Acylation: The nitrile group can undergo acylation reactions, typically with acyl chlorides or acid anhydrides, to form amides.
Substitution Reactions: The nitrile group can also undergo substitution reactions, such as amidation or esterification, to form amides or esters respectively.
Oxidation: 6-Bromonicotinonitrile can be oxidized to its corresponding carboxylic acid under certain conditions, such as using strong oxidizing agents like potassium permanganate (KMnO4) or chromic acid (H2CrO4).
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6-Bromo-4-(trifluoromethyl)nicotinonitrile