Chemistry Heterocyclic Building Blocks Pyridines 6-bromopicolinic acid
Ambeed provide 5 derivatives of 6-bromopicolinic acid.
These compounds have the same murcko framework: 6-bromopicolinic acidNucleophilic Substitution Reactions: The bromine atom on the pyridine ring makes the compound susceptible to nucleophilic substitution reactions. The bromine atom can be replaced by various nucleophiles, such as hydroxide ions or primary amines, leading to the formation of substituted products.
Esterification Reactions: The carboxylic acid group in 6-bromopicolinic acid can undergo esterification reactions with alcohols in the presence of acid catalysts to form ester derivatives.
Grignard Reactions: 6-Bromopicolinic acid can react with Grignard reagents (alkyl or aryl magnesium halides) to form substituted pyridine derivatives.
Metal Complex Formation: The carboxylic acid group can coordinate with metal ions to form metal complexes. This can be utilized in various coordination chemistry applications.
Acylation Reactions: The carboxylic acid group can undergo acylation reactions, where it reacts with acylating agents such as acyl chlorides or acid anhydrides to form amides or esters, respectively.
Reduction Reactions: The bromine atom can be reduced to a bromide ion under appropriate reaction conditions, such as using reducing agents like sodium borohydride or hydrogen gas in the presence of a catalyst.
Coupling Reactions: 6-Bromopicolinic acid can participate in coupling reactions, such as Suzuki-Miyaura coupling or Buchwald-Hartwig coupling, to form biaryl compounds or amides, respectively.
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