Chemistry Heterocyclic Building Blocks Pyridines 6-chloro-3-nitropyridin-2-amine
Ambeed provide 4 derivatives of 6-chloro-3-nitropyridin-2-amine.
These compounds have the same murcko framework: 6-chloro-3-nitropyridin-2-amineReduction: The nitro group (-NO2) can be reduced to an amino group (-NH2) using reducing agents such as hydrogen gas (H2) in the presence of a catalyst like palladium on carbon (Pd/C), or using other reducing agents like iron and hydrochloric acid (Fe/HCl).
Substitution: The chlorine atom (-Cl) can undergo substitution reactions with various nucleophiles, such as amines or hydroxide ions, leading to the formation of substituted products.
Nucleophilic aromatic substitution: The nitro group can undergo nucleophilic aromatic substitution reactions with strong nucleophiles, leading to substitution of the nitro group with the nucleophile.
Cyclization: The amine group (-NH2) can undergo cyclization reactions with suitable reagents, leading to the formation of heterocyclic compounds.
Acylation: The amine group can react with acylating agents such as acyl chlorides or acid anhydrides to form amides.
Oxidation: The amine group can be oxidized to various functional groups, such as nitroso (-NO), nitro (-NO2), or oxime (-NOH), depending on the oxidizing conditions.
Functional group interconversion: The functional groups present in the molecule can be interconverted using appropriate reagents and conditions, such as converting the amine group to other functional groups like amides, imines, or nitriles.
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