Chemistry Heterocyclic Building Blocks Pyridines 6-chloro-5-(trifluoromethyl)pyridin-2-amine
Ambeed provide 3 derivatives of 6-chloro-5-(trifluoromethyl)pyridin-2-amine.
These compounds have the same murcko framework: 6-chloro-5-(trifluoromethyl)pyridin-2-amineSubstitution Reactions: The chlorine atom and/or the amino group can undergo substitution reactions with suitable nucleophiles or electrophiles, leading to the formation of different substituted products.
Nucleophilic Addition: The amino group can undergo nucleophilic addition reactions with electrophiles, such as carbonyl compounds or alkyl halides, leading to the formation of imines or substituted amines.
Reductive Amination: The amino group can react with a suitable carbonyl compound in the presence of a reducing agent to form a substituted amine.
Acylation: The amino group can undergo acylation reactions with acyl chlorides or acid anhydrides to form amides.
Heterocyclization: The pyridine ring can participate in heterocyclization reactions with suitable reagents to form fused or spiro heterocycles.
Metalation: The pyridine ring can undergo metalation reactions with strong bases, leading to the formation of pyridine-metal complexes.
Oxidation/Reduction: The amine group can undergo oxidation reactions to form corresponding imines or oximes, while the pyridine ring can be reduced to piperidine derivatives under certain conditions.
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6-Chloro-5-(trifluoromethyl)pyridine-2,3-diamine
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6-Chloro-5-(trifluoromethyl)pyridin-2-amine
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6-Chloro-3-nitro-5-(trifluoromethyl)pyridin-2-amine