Chemistry Heterocyclic Building Blocks Pyridines 6-chloropyridin-2-ol
Ambeed provide 9 derivatives of 6-chloropyridin-2-ol.
These compounds have the same murcko framework: 6-chloropyridin-2-olSubstitution Reactions: The chlorine atom (-Cl) can undergo substitution reactions with nucleophiles to form various derivatives. For instance, it can react with amines to form N-chloroamines or with other nucleophiles to form substituted pyridines.
Esterification: The hydroxyl group (-OH) can undergo esterification with carboxylic acids or acid chlorides to form esters.
Oxidation: The hydroxyl group can undergo oxidation to form carboxylic acids or ketones under appropriate conditions.
Ether Formation: The hydroxyl group can undergo reaction with alkyl halides to form ethers.
Condensation Reactions: The compound can undergo condensation reactions with carbonyl compounds (such as aldehydes or ketones) to form heterocyclic compounds.
Metal Complex Formation: The compound can form complexes with transition metals through coordination with the oxygen and/or nitrogen atoms.
Reduction: Both the chlorine atom and the hydroxyl group can undergo reduction under appropriate conditions to form different compounds.
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2-Chloro-6-hydroxypyridine-4-carbonitrile