Chemistry Heterocyclic Building Blocks Pyridines 6-chloropyridine-3-sulfonyl chloride
Ambeed provide 5 derivatives of 6-chloropyridine-3-sulfonyl chloride.
These compounds have the same murcko framework: 6-chloropyridine-3-sulfonyl chlorideNucleophilic substitution: The chloride ion can be displaced by a nucleophile, such as a primary or secondary amine, to form a sulfonamide derivative.
Addition reactions: The sulfonyl chloride functional group can undergo addition reactions with nucleophiles, such as amines, alcohols, or thiols, to form sulfonamide, sulfonate ester, or sulfonate derivatives, respectively.
Friedel-Crafts acylation: 6-Chloropyridine-3-sulfonyl chloride can undergo Friedel-Crafts acylation with aromatic compounds in the presence of a Lewis acid catalyst, leading to the introduction of the sulfonyl group onto the aromatic ring.
Oxidation: It can undergo oxidation reactions under appropriate conditions to form sulfonyl compounds with higher oxidation states.
Reduction: It can undergo reduction reactions to yield sulfinyl or sulfanyl derivatives.
Substitution reactions: The chlorine atom can be substituted by various nucleophiles, such as amines, alcohols, or thiols, to introduce different functional groups onto the pyridine ring.
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6-Chloro-4-methylpyridine-3-sulfonyl chloride
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6-Chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride
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6-Chloro-5-fluoropyridine-3-sulfonyl chloride