Chemistry Heterocyclic Building Blocks Pyridines 6-fluoropyridin-3-amine
Ambeed provide 4 derivatives of 6-fluoropyridin-3-amine.
These compounds have the same murcko framework: 6-fluoropyridin-3-amineNucleophilic substitution reactions: The amino group can undergo substitution reactions with electrophiles. For instance, it can react with alkyl halides or acyl chlorides to form N-alkyl or N-acyl derivatives.
Amination reactions: The amino group can undergo reactions to introduce additional amino groups into the molecule. For example, it can undergo reductive amination with carbonyl compounds to form secondary or tertiary amines.
Fluorination reactions: The fluorine atom can undergo various substitution reactions, such as nucleophilic substitution or electrophilic substitution, depending on the reaction conditions and the nature of the reagents.
Cross-coupling reactions: The amino group or the fluorine atom can participate in cross-coupling reactions with appropriate coupling partners, such as aryl or alkyl halides, in the presence of suitable catalysts.
Reduction reactions: The amino group or the fluorine atom can be reduced to other functional groups. For example, the amino group can be reduced to a hydroxyl group, while the fluorine atom can be reduced to a hydrogen atom.
Substitution reactions: Both the amino group and the fluorine atom can undergo substitution reactions with appropriate nucleophiles or electrophiles to introduce different functional groups into the molecule.
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