Chemistry Heterocyclic Building Blocks Pyridines 6-methoxynicotinaldehyde
Ambeed provide 4 derivatives of 6-methoxynicotinaldehyde.
These compounds have the same murcko framework: 6-methoxynicotinaldehydeNucleophilic Addition: Since it contains an aldehyde functional group, it can undergo nucleophilic addition reactions with nucleophiles such as Grignard reagents, organolithium compounds, or cyanide ions.
Aldol Condensation: 6-methoxynicotinaldehyde can undergo aldol condensation reactions with itself or other carbonyl compounds in the presence of a base, resulting in the formation of β-hydroxy aldehydes or ketones.
Oxidation: Like other aldehydes, it can be oxidized to the corresponding carboxylic acid under appropriate conditions, such as using oxidizing agents like potassium permanganate (KMnO4) or chromic acid (H2CrO4).
Reduction: It can undergo reduction reactions to yield the corresponding alcohol using reducing agents such as sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4).
Aromatic Substitution: The aromatic ring in 6-methoxynicotinaldehyde can undergo electrophilic aromatic substitution reactions with strong electrophiles, such as nitration, halogenation, or sulfonation.
Mannich Reaction: It can participate in Mannich reactions where it reacts with formaldehyde and a secondary amine to form β-amino aldehydes.
Schiff Base Formation: 6-methoxynicotinaldehyde can react with primary amines to form Schiff bases, which are important intermediates in various organic reactions.
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6-Methoxy-4-(trifluoromethyl)nicotinaldehyde