Chemistry Heterocyclic Building Blocks Pyridines 6-methoxypyridin-3-amine
Ambeed provide 8 derivatives of 6-methoxypyridin-3-amine.
These compounds have the same murcko framework: 6-methoxypyridin-3-amineSubstitution Reactions: The amino group can undergo substitution reactions, where it can be replaced by other functional groups or atoms. For example, it can react with acyl chlorides to form amides, or with alkyl halides to form substituted amines.
Nucleophilic Aromatic Substitution (SNAr): The electron-rich nature of the amino group makes it a potential nucleophile in aromatic substitution reactions. It can attack electrophilic centers on the pyridine ring, leading to substitution reactions.
Redox Reactions: The amine group can undergo redox reactions, where it can be oxidized or reduced depending on the reaction conditions. For example, it can be oxidized to form an N-oxide or undergo reductive amination reactions.
Condensation Reactions: The amino group can participate in condensation reactions with carbonyl compounds, leading to the formation of imines or enamines.
Metal Complexation: The amino group can act as a ligand and coordinate with metal ions, forming metal-amino complexes.
Base-Catalyzed Reactions: The amino group can undergo various base-catalyzed reactions such as Hofmann elimination, where it can be converted into an alkene.
Acid-Catalyzed Reactions: The presence of the amino group allows for acid-catalyzed reactions such as protonation, dehydration, or hydrolysis.
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6-Methoxy-N4-methylpyridine-3,4-diamine