Chemistry Heterocyclic Building Blocks Pyridines 6-methylpyridin-3-amine
Ambeed provide 5 derivatives of 6-methylpyridin-3-amine.
These compounds have the same murcko framework: 6-methylpyridin-3-amineNucleophilic substitution reactions: The amino group in the molecule can undergo nucleophilic substitution reactions with electrophiles. For example, it can react with alkyl halides to form N-alkylated products.
Acylation reactions: The amine group can react with acyl chlorides or acid anhydrides to form amides. This reaction is known as acylation.
Reductive amination: The amine group can undergo reductive amination reactions with aldehydes or ketones in the presence of reducing agents such as sodium cyanoborohydride or sodium triacetoxyborohydride. This reaction forms secondary or tertiary amines, depending on the starting materials.
Diazo coupling: The amine group can participate in diazo coupling reactions, where it reacts with diazonium salts to form azo compounds. This reaction is often used in dye synthesis.
Electrophilic aromatic substitution: The aromatic ring in 6-methylpyridin-3-amine can undergo electrophilic aromatic substitution reactions, similar to benzene. For example, it can react with strong electrophiles such as nitronium ion or acyl chlorides under appropriate conditions.
Oxidation reactions: The amine group can be oxidized to form various products, depending on the oxidizing agent used. For example, it can be oxidized to form amine oxides or further oxidized to form nitriles or nitro compounds.
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6-Methyl-5-(trifluoromethyl)pyridin-3-amine