Chemistry Heterocyclic Building Blocks Pyridines 6-methylpyridin-3-ol
Ambeed provide 7 derivatives of 6-methylpyridin-3-ol.
These compounds have the same murcko framework: 6-methylpyridin-3-olSubstitution Reactions: The hydroxyl group in 6-methylpyridin-3-ol can undergo substitution reactions, where it is replaced by another functional group. Common substitution reactions include halogenation (replacement by a halogen atom such as chlorine or bromine) and alkylation (replacement by an alkyl group).
Oxidation Reactions: The hydroxyl group can undergo oxidation to form various oxidation products. For instance, it can be oxidized to form aldehydes, ketones, or carboxylic acids, depending on the reaction conditions and reagents used.
Esterification: The hydroxyl group can react with carboxylic acids or acid chlorides to form esters. This reaction is often catalyzed by acid catalysts such as sulfuric acid or hydrochloric acid.
Acetylation: The hydroxyl group can react with acetic anhydride or acetyl chloride to form the corresponding acetate ester.
Condensation Reactions: 6-methylpyridin-3-ol can undergo condensation reactions with carbonyl compounds to form Schiff bases or other condensation products.
Reduction Reactions: The carbonyl group, if present (as in an oxidized product), can undergo reduction to form alcohols or even hydrocarbons, depending on the reaction conditions and reagents used.
Nucleophilic Substitution Reactions: If there are suitable leaving groups attached to the pyridine ring, nucleophilic substitution reactions can occur. This can lead to various substitution products depending on the nature of the nucleophile.
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