Chemistry Heterocyclic Building Blocks Piperidines 7-azaspiro[3.5]nonane
Ambeed provide 7 derivatives of 7-azaspiro[3.5]nonane.
These compounds have the same murcko framework: 7-azaspiro[3.5]nonane.
Basic Hydrolysis: 7-Azaspiro[3.5]nonane can undergo basic hydrolysis of its nitrogen-containing functional groups. For example, if it contains an amide group, it can be hydrolyzed to yield the corresponding amine and carboxylic acid.
Acid-Catalyzed Hydrolysis: Under acidic conditions, amides, imides, and other nitrogen-containing groups can be hydrolyzed as well.
Nucleophilic Substitution Reactions: If there are suitable leaving groups or electrophilic centers in the molecule, nucleophilic substitution reactions can occur. For example, an amine group can act as a nucleophile and displace a leaving group under appropriate conditions.
Reduction Reactions: 7-Azaspiro[3.5]nonane may be susceptible to reduction by various reducing agents, leading to the formation of products with reduced nitrogen functionality.
Oxidation Reactions: Depending on its structure, the compound can undergo oxidation reactions, introducing oxygen-containing functional groups.
Ring-Opening Reactions: The spirocyclic ring of 7-azaspiro[3.5]nonane can potentially open under certain conditions, leading to the formation of open-chain compounds.
Substitution Reactions: If there are halogen atoms or other substituents on the molecule, they can undergo substitution reactions with nucleophiles or other reactive species.
Cyclization Reactions: Intramolecular cyclization reactions can occur if the molecule has suitable functional groups that can react to form a different cyclic structure.
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tert-butyl 2-(2-hydroxyethyl)-7-azaspiro[3.5]nonane-7-carboxylate
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tert-butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate
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tert-butyl 2-bromo-7-azaspiro[3.5]nonane-7-carboxylate
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7-Boc-7-azaspiro[3.5]nonane-2-carboxylic acid
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tert-butyl 2-amino-7-azaspiro[3.5]nonane-7-carboxylate
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tert-butyl N-{7-azaspiro[3.5]nonan-2-yl}carbamate