Chemistry Heterocyclic Building Blocks Indoles 7-bromo-1H-indole

7-bromo-1H-indole

Ambeed provide 28 derivatives of 7-bromo-1H-indole.

These compounds have the same murcko framework: indole

Nucleophilic Substitution: The bromine atom at the 7th position is a good leaving group, and nucleophiles can attack the carbon adjacent to the bromine. This can lead to substitution reactions, where the bromine is replaced by another nucleophile.
Cross-Coupling Reactions: Palladium-catalyzed cross-coupling reactions, such as Suzuki or Stille coupling, can be performed using 7-bromo-1H-indole as a substrate. This allows the introduction of various substituents at the 7th position through coupling with different organometallic compounds.
Grignard Reaction: 7-bromo-1H-indole can react with Grignard reagents, leading to the formation of substituted indole derivatives.
Suzuki-Miyaura Coupling: In this reaction, 7-bromo-1H-indole can be coupled with boronic acids or boronate esters in the presence of a palladium catalyst to form biaryl compounds.
Reduction: The bromine substituent can be reduced to an alkyl group using reducing agents such as lithium aluminum hydride (LiAlH4) or other suitable reducing agents.
Oxidation: The compound can be oxidized to generate indole-7-carboxylic acids or other oxidized derivatives.
Halogen-Metal Exchange: 7-bromo-1H-indole may undergo halogen-metal exchange reactions, where the bromine is replaced by another halogen through reaction with a strong base and a halogen source.

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Conditions to empty

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(1-(tert-butoxycarbonyl)-1H-indol-2-yl)boronic acid (1H-indol-2-yl)boronic acid (1H-indol-2-yl)methanol (3aS,7aS)-octahydro-1H-indole (9H-fluoren-9-yl)methyl (2-(1H-indol-3-yl)ethyl)carbamate 1,2,3,4-tetrahydrocyclopenta[b]indole 1,2-dimethyl-1H-indole 1-(1H-indol-1-yl)ethan-1-one 1-(1H-indol-3-yl)-N,N-dimethylmethanamine 1-(1H-indol-3-yl)ethan-1-one 1-(phenylsulfonyl)-1H-indole 1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine 1-benzyl-1H-indole 1-ethyl-1H-indole 1-methyl-1H-indole 1-methyl-1H-indole-2-carboxylic acid 1-methyl-1H-indole-3-carbaldehyde 1-methyl-1H-pyrrolo[2,3-b]pyridine 1-phenyl-1H-indole 1H-indol-3-ol 1H-indol-3-yl acetate 1H-indol-4-amine 1H-indol-4-ol 1H-indol-5-ol 1H-indol-6-amine 1H-indol-6-ol 1H-indol-7-amine 1H-indole-2-carbaldehyde 1H-indole-2-carbonitrile 1H-indole-3-carbaldehyde 1H-indole-3-carbonitrile 1H-indole-3-carboxylic acid 1H-indole-4-carboxylic acid 1H-indole-5-carbonitrile 1H-indole-5-carboxylic acid 1H-indole-6-carbonitrile 1H-indole-6-carboxylic acid 1H-indole-7-carbonitrile 1H-indole-7-carboxylic acid 1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole 2,3-dimethyl-1H-indole 2-(1,3,2-dioxaborolan-2-yl)-1-methyl-1H-indole 2-(1H-indol-1-yl)acetic acid 2-(1H-indol-3-yl)acetic acid 2-(1H-indol-3-yl)ethan-1-amine 2-(1H-indol-3-yl)ethan-1-ol 2-(2-methyl-1H-indol-3-yl)acetic acid 2-(4-fluorophenyl)-1H-indole 2-methyl-1H-indole-3-carbaldehyde 2-methyl-1H-pyrrolo[2,3-b]pyridine 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione 3-(1H-indol-3-yl)propanoic acid 3-(piperidin-4-yl)-1H-indole 3-iodo-1H-pyrrolo[2,3-b]pyridine 3-methyl-1H-indole 3H-indole 4-bromo-1H-indole 4-chloro-1H-indole 4-fluoro-1H-indole 4-fluoro-1H-pyrrolo[2,3-b]pyridine 4-fluoroindoline-2,3-dione 4-methoxy-1H-indole 4-methyl-1H-indole 4-nitro-1H-indole 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 5-(benzyloxy)-1H-indole 5-bromo-1-methyl-1H-indole 5-chloro-1H-indole 5-chloro-1H-indole-2-carboxylic acid 5-chloro-1H-pyrrolo[2,3-b]pyridine 5-fluoro-1H-indole 5-fluoro-1H-pyrrolo[2,3-b]pyridine 5-fluoroindolin-2-one 5-methoxy-1H-indole 5-methoxy-2-methyl-1H-indole 5-methyl-1H-indole 5-nitro-1H-indole 6-(trifluoromethyl)-1H-indole 6-bromo-1-methyl-1H-indole 6-bromo-1H-indole 6-bromo-1H-pyrrolo[2,3-b]pyridine 6-chloro-1H-indole 6-chloro-1H-pyrrolo[2,3-b]pyridine 6-fluoro-1H-indole 6-methoxy-1H-indole 6-methyl-1H-indole 6-methyl-1H-pyrrolo[2,3-b]pyridine 6-nitro-1H-indole 7-bromo-1H-indole 7-bromoindoline-2,3-dione 7-chloro-1H-indole 7-fluoro-1H-indole 7-fluoro-1H-indole-2-carboxylic acid 7-methoxy-1H-indole 7-methyl-1H-indole 7-nitro-1H-indole 9H-pyrido[3,4-b]indole benzo[cd]indol-2(1H)-one ethyl 1H-indole-3-carboxylate ethyl 5-chloro-1H-indole-2-carboxylate ethyl 5-fluoro-1H-indole-2-carboxylate ethyl 6-chloro-1H-indole-2-carboxylate ethyl 7-chloro-1H-indole-2-carboxylate methyl 1H-indole-3-carboxylate methyl 1H-indole-4-carboxylate methyl 1H-indole-5-carboxylate methyl 1H-indole-6-carboxylate methyl 1H-indole-7-carboxylate methyl 2-(1H-indol-3-yl)acetate N-(2-(1H-indol-3-yl)ethyl)acetamide spiro[indoline-3,4'-piperidin]-2-one tert-butyl 1H-indole-1-carboxylate tert-butyl 1H-pyrrolo[2,3-b]pyridine-1-carboxylate tert-butyl 2-(1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate tert-butyl 3-(hydroxymethyl)-1H-indole-1-carboxylate tert-butyl 3-bromo-1H-indole-1-carboxylate tert-butyl 3-iodo-1H-indole-1-carboxylate tert-butyl 5-methoxy-1H-indole-1-carboxylate tryptophan

By Key Group+−

aminoindole azaindole benzoindole benzyloxyindole biindolinylidene boronate-indole bromo-indole-carboxylate bromo-indole-carboxylic acid bromo-methyl-indole bromoindole chlorindole-carboxylic acid chloro-indole-carboxylate chloro-methyl indole chloroindole cyanoindole dihydroindolo dimethyl-indole dioxaborolan-indole dioxaborolan-indole-carboxylate fluorindole-carboxylic acid fluoro-indole-carboxylate fluoroindole fluoromethyl-indole formyl-indole-carboxylate formylindole hydroxyindole hydroxyisoindoline hydroxymethy-indole-carboxylate indol-amine indol-methanamine indol-methanol indol-one indole-boronic acid/ester indole-carbonitrile indole-ethanol indole-ethylamine indole-hydrochloride indole-hydroxyl indolecarboxylate indolecarboxylic iodo-indole isoindole methanoisoindole methoxy-indole-carboxylate methoxy-methyl-indole methoxyindole methyl-indole-carboxylic-acid methyl-nitro-indole methylindole nitro-indole-carboxylate nitroindole phenyl-indole piperidine-indole pyridinoindole pyrimido-indole trifluoromethyl-indole

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    By Configuration+−

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