Chemistry Heterocyclic Building Blocks Imidazoles 8-methylimidazo[1,2-a]pyridine

8-methylimidazo[1,2-a]pyridine

Ambeed provide 9 derivatives of 8-methylimidazo[1,2-a]pyridine.

These compounds have the same murcko framework: 8-methylimidazo[1,2-a]pyridine

Substitution Reactions: The methyl group at the 8-position could potentially undergo substitution reactions. For example, it might be replaced by another functional group in the presence of appropriate reagents.
Aromatic Electrophilic Substitution: The aromatic nature of the imidazo[1,2-a]pyridine ring suggests that it might undergo electrophilic aromatic substitution reactions. This could involve the introduction of various substituents under the influence of electrophiles.
Reduction Reactions: The imine nitrogen in the imidazo[1,2-a]pyridine ring might be reducible, leading to the formation of a saturated derivative, such as a dihydroimidazo[1,2-a]pyridine.
Nucleophilic Substitution: Depending on the reaction conditions, nucleophiles could potentially substitute other atoms or groups within the molecule.
Metalation Reactions: The imidazo[1,2-a]pyridine ring might be susceptible to metalation reactions, where a metal atom replaces a hydrogen atom on the ring.
Oxidation Reactions: The methyl group or other functional groups within the molecule might be oxidizable under certain conditions.
Condensation Reactions: Depending on the presence of suitable functional groups, 8-methylimidazo[1,2-a]pyridine might participate in condensation reactions to form larger cyclic or acyclic structures.

Further Reading:
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Purity
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Conditions to empty

Framework+−

1,1'-diphenyl-4,4',5,5'-tetrahydro-1H,1'H-2,2'-biimidazole 1,2-dimethyl-1H-imidazole 1,3-diphenyl-1H-imidazol-3-ium 1,3-diphenyl-4,5-dihydro-1H-imidazol-3-ium 1-(imidazo[1,2-a]pyridin-3-yl)ethan-1-one 1-(phenylsulfonyl)-1H-imidazole 1-benzyl-1H-imidazole 1-decyl-3-methyl-1H-imidazol-3-ium 1-ethyl-1H-imidazole 1-isopropyl-1H-imidazole 1-phenyl-1H-imidazole-4-carboxylic acid 1-trityl-1H-imidazole 1H-imidazo[4,5-b]pyridine 1H-imidazo[4,5-c]pyridine 1H-imidazol-2-amine 1H-imidazole-2-carboxylic acid 1H-imidazole-4-carbonitrile 1H-imidazole-4-carboxylic acid 2-(pyridin-2-yl)-1H-benzo[d]imidazole 2-bromo-1H-imidazole 2-bromoimidazo[1,2-a]pyridine 2-ethyl-1H-imidazole 2-methyl-1-phenyl-1H-imidazole 2-methylimidazo[1,2-a]pyridine 2-phenyl-1H-benzo[d]imidazole 2-phenyl-1H-imidazole 2-phenylimidazo[1,2-a]pyridine 2-propyl-1H-imidazole 3-bromoimidazo[1,2-a]pyrazine 3-bromoimidazo[1,2-a]pyridine 3-bromoimidazo[1,2-a]pyrimidine 3-iodoimidazo[1,2-a]pyridine 3-methylimidazo[1,2-a]pyridine 4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine 4-(1H-imidazol-1-yl)benzaldehyde 4-bromo-1-phenyl-1H-imidazole 4-methyl-1-phenyl-1H-imidazole 4-methyl-1H-imidazole 4-phenyl-1H-imidazole 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine 5-benzyl-1H-imidazole 5-bromoimidazo[1,2-a]pyridine 5-chloro-1H-imidazole 5-fluoro-1H-benzo[d]imidazole 5-iodo-1H-imidazole 5-methylimidazo[1,2-a]pyridine 5-phenyl-1H-imidazole 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole 6-bromoimidazo[1,2-a]pyrazine 6-bromoimidazo[1,2-a]pyridine 6-bromoimidazo[1,2-a]pyrimidine 6-chloroimidazo[1,2-a]pyridine 6-chloroimidazo[1,2-b]pyridazine 7-methylimidazo[1,2-a]pyridine 8-bromoimidazo[1,2-a]pyrazine 8-bromoimidazo[1,2-a]pyridine 8-chloroimidazo[1,2-a]pyrazine 8-chloroimidazo[1,2-a]pyridine 8-fluoroimidazo[1,2-a]pyridine 8-methylimidazo[1,2-a]pyridine ethyl 1H-imidazole-2-carboxylate ethyl 2-(imidazo[1,2-a]pyridin-3-yl)acetate ethyl imidazo[1,2-a]pyridine-2-carboxylate ethyl imidazo[1,2-a]pyridine-3-carboxylate imidazo[1,2-a]pyridin-3-amine imidazo[1,2-a]pyridin-8-amine imidazo[1,2-a]pyridin-8-ol imidazo[1,2-a]pyridine-2-carbaldehyde imidazo[1,2-a]pyridine-2-carboxylic acid imidazo[1,2-a]pyridine-3-carbaldehyde imidazo[1,2-a]pyridine-3-carboxylic acid imidazo[1,2-a]pyridine-7-carboxylic acid imidazo[1,2-a]pyridine-8-carboxylic acid imidazo[1,2-a]pyrimidine-3-carboxylic acid imidazo[1,2-c]pyrimidine imidazo[1,5-a]pyrazine imidazo[2,1-b]thiazole methyl 1H-imidazole-2-carboxylate methyl 1H-imidazole-5-carboxylate methyl imidazo[1,2-a]pyridine-8-carboxylate tert-butyl 1H-imidazole-1-carboxylate

By Key Group+−

aminoimidazole-carboxylate benzyl-imidazole benzyl-methyl-imidazole biimidazole bromo-imidazole bromo-imidazopyridine bromo-methyl-imidazole bromoimidazo bromoimidazole carboxylate chloro-imidazopyridine chloroimidazo dibromoimidazo dichloroimidazo dihydroimidazo dimethyl-imidazol dimethylimidazo dimethylimidazolium dioxaborolane-imidazole ethyl-imidazole fluoroimidazo hydroxy-imidazopyridine imidazol-amine imidazol-ethanol imidazol-hydrochloride imidazol-ium imidazol-methanamine imidazol-methanol imidazol-nitrile imidazol-pyridine imidazole-carboxylate imidazole-carboxylic acid imidazolyl-pyrimidine imidazopyrazine imidazopyridazine imidazopyridin-amine imidazopyridin-one imidazopyridine imidazopyridine-carbonitrile imidazopyridine-carboxylate imidazopyridine-carboxylic acid imidazopyrimidine imidazoquinoline imidazothiazole iodoimidazo iodomethyl-imidazole isopropyl-imidazole methoxyimidazo methyl-imidazopyridine methyl-nitro-imidazole methylimidazo methylimidazole methylimidazolium nitro-imidazole-carboxylate nitroimidazole phenylimidazo phenylimidazole piperidin-imidazolyl pyrroloimidazole tetrahydroimidazo thienoimidazol trifluoromethyl-imidazo trifluoromethyl-imidazole trifluoromethyl-imidazopyridine

By Parent Nucleus+−

Aliphatic Heterocycles Aromatic Heterocycles Dioxolanes Indazoles Other Aliphatic Heterocycles Other Aromatic Heterocycles Piperazines Piperidines Pyrazines Pyrazoles Pyridines Pyrimidines Pyrrolidines Spiroes Tetrahydropyrans Thiophenes Thiophenols Triazines Triazoles

By Functional Group+−

Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkynyls Amides Amines Aryls Benzyl bromides Benzyl Chlorides Bromides Carboxylic Acids Chiral Building Blocks Chlorides Esters Ethers Fluorinated Building Blocks Hydrazines Iodides Ketones Nitriles Nitroes Organoboron Oximes Phenols Phosphoruses Sulfamides Sulfides Sulfonates Sulfones Sulfonic Acids Sulfonyl Chlorides Sulfoxides Thioureas Trifluoromethyls Ureas

By Chemical Elements+−

    Bx
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    Formula Weight+−

    cLogP+−

    H-Acceptors+−

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    Polar Surface Area+−

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    NNCH/NNH+−

    sp3-Atoms+−

    Non-Aromatic Rings+−

    Aromatic Rings+−

    Rotatable Bonds+−

    By Configuration+−

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