Chemistry Heterocyclic Building Blocks Indoles 9H-pyrido[3,4-b]indole
Ambeed provide 5 derivatives of 9H-pyrido[3,4-b]indole.
These compounds have the same murcko framework: 9H-pyrido[3,4-b]indole.
Aromatic Substitution: 9H-pyrido[3,4-b]indole contains an aromatic ring, which can undergo electrophilic aromatic substitution reactions. For example, you can perform halogenation (e.g., bromination or chlorination) or nitration to introduce various substituents onto the aromatic ring.
Reduction: Reduction reactions can convert the imine group to the corresponding amine. Common reducing agents like hydrogen gas (catalytic hydrogenation) or hydride reagents (e.g., NaBH4) can be used.
Alkylation or Acylation: You can introduce alkyl or acyl groups onto the nitrogen or carbon atoms of the indole ring using appropriate alkylating or acylating agents under suitable conditions.
Oxidation: You can oxidize the indole ring using reagents like chromic acid (Jones reagent) or other mild oxidizing agents.
Cyclization: Depending on the reaction conditions and the substituents present, intramolecular cyclization reactions may occur. This can lead to the formation of various cyclic compounds.
Grignard Reaction: If there are appropriate functional groups, you can react 9H-pyrido[3,4-b]indole with Grignard reagents to introduce various substituents onto the molecule.
Heterocycle Formation: You can use 9H-pyrido[3,4-b]indole as a starting material to create more complex heterocycles through various cyclization reactions.
Cross-Coupling Reactions: If suitable functional groups are present, you can perform cross-coupling reactions, such as Suzuki coupling or Heck reaction, to create new carbon-carbon bonds.
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tert-Butyl 9H-pyrido[3,4-b]indole-3-carboxylate