Chemistry Heterocyclic Building Blocks Pyridines bis(pyridin-2-ylmethyl)amine
Ambeed provide 6 derivatives of bis(pyridin-2-ylmethyl)amine.
These compounds have the same murcko framework: bis(pyridin-2-ylmethyl)amine.
Nucleophilic Substitution: The amine nitrogen can act as a nucleophile in substitution reactions with electrophiles. For example, it can react with alkyl halides to form N-alkylated derivatives.
Metalation: The pyridine rings can coordinate with various transition metals, making it a potentially useful ligand in coordination chemistry. These metal complexes can participate in a wide range of reactions, such as oxidative addition, reductive elimination, and catalytic processes.
Reduction: The amine group can be reduced to form the corresponding amine or undergo reductive amination reactions.
Alkylation and Acylation: The amine can be alkylated or acylated to introduce various substituents onto the nitrogen atom.
Condensation Reactions: Bis(pyridin-2-ylmethyl)amine can participate in condensation reactions with carbonyl compounds, leading to imine or enamine formation.
Cross-Coupling Reactions: It can be used in cross-coupling reactions, such as Suzuki-Miyaura or Heck reactions, when the pyridine rings are functionalized with suitable leaving groups.
Oxidation: The amine can be oxidized to form the corresponding amine oxide or other oxidation products.
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Bis((6-bromopyridin-2-yl)methyl)amine
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(Prop-2-yn-1-yl)bis[(pyridin-2-yl)methyl]amine
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N1,N1-Bis(pyridin-2-ylmethyl)ethane-1,2-diamine
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2-(Bis(pyridin-2-ylmethyl)amino)-2-(hydroxymethyl)propane-1,3-diol