Chemistry Organic Building Blocks Aryls cyclopropyl(phenyl)methanone
Reduction: The ketone group can be reduced to an alcohol using reducing agents like sodium borohydride (NaBH4) or lithium aluminum hydride (LiAlH4). This would yield cyclopropyl(phenyl)methanol.
Aldol Reaction: Cyclopropyl(phenyl)methanone can participate in aldol condensation reactions, leading to the formation of a new carbon-carbon bond between two ketone or aldehyde molecules.
Friedel-Crafts Acylation: The phenyl group in the compound can undergo acylation reactions via Friedel-Crafts acylation, where an acyl group is added to the phenyl ring. This is typically carried out with acyl chloride or anhydrides in the presence of Lewis acids like aluminum chloride (AlCl3).
Cycloaddition Reactions: The strained cyclopropyl ring can participate in various cycloaddition reactions, such as Diels-Alder reactions, which can lead to the formation of complex cyclic compounds.
Oxidation: The ketone group can be oxidized to a carboxylic acid or other oxidized derivatives using reagents like potassium permanganate (KMnO4) or Jones reagent (chromic acid).
Nucleophilic Addition: The ketone group can react with nucleophiles, such as Grignard reagents, to form alcohol derivatives.
Ring-Opening Reactions: The cyclopropyl ring is highly strained and can be opened under certain conditions, leading to the formation of new compounds.
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(5-Bromo-2-fluorophenyl)(cyclopropyl)methanone
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Ethyl 4-(cyclopropanecarbonyl)benzoate
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4-Chloro-2-fluorophenyl cyclopropyl ketone
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(4-(Bromomethyl)phenyl)(cyclopropyl)methanone