Chemistry Heterocyclic Building Blocks Pyridines ethyl 2-(pyridin-2-yl)acetate
Ambeed provide 15 derivatives of ethyl 2-(pyridin-2-yl)acetate.
These compounds have the same murcko framework: ethyl 2-(pyridin-2-yl)acetateHydrolysis: Ethyl 2-(pyridin-2-yl)acetate can undergo hydrolysis in the presence of water or aqueous acids to yield 2-(pyridin-2-yl)acetic acid and ethanol.
Esterification: It can react with acids (e.g., acetic acid) or acid chlorides to form corresponding esters under acidic conditions.
Reduction: Reduction reactions can convert the carbonyl group of the ester into a hydroxyl group or an alcohol. Common reducing agents include lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Grignard Reaction: Ethyl 2-(pyridin-2-yl)acetate can react with Grignard reagents (RMgX) to yield substituted ketones.
Substitution Reactions: The ester functionality can undergo substitution reactions, such as nucleophilic acyl substitution, with various nucleophiles under appropriate conditions.
Oxidation: Under strong oxidizing conditions, the compound can undergo oxidation to form corresponding carboxylic acids.
Alkylation: It can react with alkyl halides in the presence of a base to undergo alkylation, where the alkyl group replaces the ethyl group of the ester.
Condensation Reactions: Ethyl 2-(pyridin-2-yl)acetate can participate in condensation reactions with other compounds containing active hydrogen atoms, forming new bonds and products.
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Ethyl 2-(3-nitropyridin-2-yl)acetate
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Ethyl 2-(5-bromo-3-nitropyridin-2-yl)acetate
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Ethyl 2-(6-((tert-butoxycarbonyl)amino)pyridin-2-yl)acetate
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Ethyl 2-(5-chloropyridin-2-yl)acetate
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Ethyl 2-(4-(trifluoromethyl)pyridin-2-yl)acetate
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Ethyl 2-(3-aminopyridin-2-yl)acetate